Also, studies on triple transgenic model of AD (3xTg AD) expressing 3 dementia-related transgenes, namely APPSWE, PS1M146V, and tauP301L and raised on high-fat diet as well as STZ-induced diabetic APP/PS1 dual transgenic AD mice demonstrate increased RAGE expression in neurons and astrocytes with an activation of pro-inflammatory cytokines and enhanced decline of cognitive and memory functions (Choi et al., 2014). This evidence concerns the gene PSEN1 and Alzheimer disease.