In another significant study, scientists showed that systemic immune challenge elicited by injecting viral mimics of polyriboinosinic-polyribocytidilic acid resulted in “sporadic AD” like features in wild-type mouse models accompanied by Aβ deposition, tau pathology, microglia activation, and reactive gliosis implying that alterations in the immune system can precede AD pathology and drive the disease itself (Michalovicz et al., 2015). Here, MAPT is linked to Alzheimer disease.