For instance, independent of its enzymatic action, AChE can modulate calcium (Ca2+) influx (Soreq and Seidman, 2001; Greenfield, 2013; Zimmermann, 2013; Garcia-Ratés et al., 2016), which subsequently can trigger trophic or toxic mechanisms depending on its dose (Bon and Greenfield, 2003; Greenfield et al., 2004), exposure time (Day and Greenfield, 2003) and, of most relevance to AD, the age of the brain in question (Eimerl and Schramm, 1994; Riascos et al., 2011). The gene discussed is ACHE; the disease is Alzheimer disease.