CHRNA7 and Alzheimer disease: In addition, our observations are in line with other studies describing a functional interaction between α7-nAChR, p-Tau, and Aβ and their implication in AD pathobiology (Wang et al., 2000a,b; Nagele et al., 2002; Rubio et al., 2006; Oz et al., 2013; Dineley et al., 2015).