LGALS1 and metastatic melanoma: However, a study using bevacizumab (antibody against vascular endothelial growth factor) and ipilimumab (antibody against cytotoxic T-lymphocyte-associated antigen 4) on patients with metastatic melanoma found that patients with therapeutic responses made antibodies against galectin-1, whilst a group of patients with reduced survival had increased circulating galectin-1 protein levels [103].