Taken together, our results indicated that liraglutide upregulated SP-A expression in ATII cells and attenuated pulmonary inflammation, pulmonary edema, and increase in insulin level in LPS-induced ALI, most likely through the TTF-1 signaling pathway, suggesting that liraglutide may be considered an effective drug for the potential treatment of ARDS in the future. Here, TTF1 is linked to acute respiratory distress syndrome.