FZD4 and cancer: In our study, over time, a total of 22 GPCR DEG (in italic in Supplementary Tables 2, 3, and 4) have been identified to be involved in the development of cancer of which 7 genes coding for Wnt signalling, frizzleds and receptors of endothelins, prostaglandins, and thrombin were related to growth, metastasis, survival, angiogenesis, and migration of colorectal cancer49,50.