In these pathways 6 genes were related to cancer like pancreas cancer (Ramp1 and Cckbr)16,18,19, melanoma (Plcb4)20, cervical and ovarian (Adcyap1 and Trpc3)21,22, and colorectal cancer (Ptger3)23. This evidence concerns the gene PLCB4 and pancreatic neoplasm.