VGLL4 and neoplasm: Based on the analysis of clinical database, we found that high 5-HT level was prominently related to higher PLT (P < 0.001), larger tumor size (P < 0.001), more death (P = 0.002) and higher YAP/VGLL4 ratio (P = 0.016) and high YAP/VGLL4 ratio was related to higher ALP (P = 0.010), higher GGT (P < 0.001) and larger tumor size (P < 0.001), easier vascular invasion (P = 0.001), more death (P < 0.001) and a higher 5-HT level (P = 0.016) (Table 1).