It indicated that PIAS3 is expressed in nuclei of normal astrocytes in vitro (Supplementary Figure 1b) and in vivo (Supplementary Figure 4a), cytoplasm of neurons (Supplementary Figure 4b) in vivo, and nuclei of glioma cells in GBM tissues (Supplementary Figure 4c). The gene discussed is PIAS3; the disease is central nervous system cancer.