SMCR8 and Autoimmunity: To further confirm that the elevated anti-dsDNA antibodies seen in the Smcr8−/− mice were due to autoimmunity instead of dramatic synchronized cell death, we collected plasma from 250-d-old wild-type (n = 3), C9orf72−/− (n = 2), and Smcr8 CRISPR F0 (n = 21) mice and analyzed the levels of autoantibodies against a panel of 124 autoantigens (Li et al. 2005).