For example, variants in HLA-B are associated to the progression to clinical disease after HIV infection (The International HIV Controllers Study 2010), variants in HLA-C, -DP and -DQ are associated to clearance of hepatitis B virus (Hu et al. 2013), alleles in HLA-DRB1 are associated to susceptibility or resistance to leprosy (Vanderborght et al. 2007) and alleles at HLA-B, -DQ and -DR are associated to resistance to severe malaria (Hill et al. 1991). This evidence concerns the gene HLA-B and malaria.