Furthermore, compatibility with JQC at the five ratios all significantly promoted nuclear translocation of Nrf2 and activated HO-1, NQO1, and GCLC mRNA expression, suggesting that the activation of Nrf2 and it-target downstream genes could involve the protection of compatibility with JQC against LGT-induced hepatotoxicity in tumor-bearing mice. This evidence concerns the gene HMOX1 and neoplasm.