Compared to the control IgG group, neutralizationof ST2L significantly decreased the tumor size in tumor-bearing mice (P< .05; Figure 5A), accompaniedby inhibition of the serum ST2L, but not sST2 and IL-33, suggesting neutralization of ST2Lmay not regulate sST2 and IL-33 expression (Figure 5B-D). The gene discussed is IL33; the disease is neoplasm.