ST2L+Treg cells had been reported to express high levels of KLRG1, CD103, andOX40, suggesting that they were activated and had regulatory functions.10 Suppression experiments performed after cell sorting ofST2L+CD4+CD25+ T cell from tumor specimens showed thatthey could suppress splenic CD4+ effector T-cell(CD4+CD25–) proliferation and Th1 cytokine secretion; however,ST2L−CD4+CD25+ T cells had lower suppression function.ST2L−Treg cells had been reported to impair their suppression ability torestrain inflammation,10 which supported our results. The gene discussed is CD4; the disease is neoplasm.