However, the levels of sST2 were negatively associated with tumor size, which werecorresponded to O’Donnell et al’s study.29 In addition, we found that the frequency of ST2L+Treg cells and relatedcytokines (IL-4, IL-10, and IL-13) in the CRC mice were significantly increased but notST2L−Treg cells, suggesting that ST2L+Treg cells maybe the mainsubpopulation that play important roles in the immunosuppression and promoting thedevelopment of CRC. This evidence concerns the gene IL10 and neoplasm.