Similarly, IL-33 can promote antiinflammatory cytokinesproduction in cutaneous fibrosis and inflammatory bowel disease, respectively.32, -34 Rank et al found that IL-33-activated DCs prime naiveCD4+ T cells to produce Th2-type cytokines.34 We also used neutralizing mouse anti-ST2L antibody to study the role of IL-33downstream on the development of CRC. Here, IL33 is linked to inflammatory bowel disease.