He et al investigated the role of epithelial expressed IL-33 duringdevelopment of intestinal tumors and found that the expression of IL-33 within epithelialcells promoted tumor development by using ApcMin/+ or V33ApcMin/+ transgenic mice.31 Our study examined the effects of IL-33/ST2L signaling in regulatingtumor-infiltrating ST2L+Treg cells on CRC development after administration ofrecombinant IL-33 or neutralizing antibody. The gene discussed is IL33; the disease is colorectal carcinoma.