Different from PEX1, there was an accordance between HPGD up-regulation in NF-κB-silencing for MDA-MB-231 and HCC-1954, showing that HPGD may play a tumor suppressor role, as reported by Pham et al. [38] and Thiel et al. [39]. The gene discussed is PEX1; the disease is hepatocellular carcinoma.