Furthermore, downregulation of MCL-1 protein by NVP-BEZ235 further contributed to the modulation of GC-resistance by increasing the amount of BIM available to induce apoptosis, especially in PTEN-null T-ALL cells, where the inhibition of Akt only partially overcame Akt-induced BIM suppression [143]. This evidence concerns the gene PTEN and acute lymphoblastic leukemia.