Therefore, this study provided evidence that mTORC2 is an important determinant of the capacity of active NOTCH1 to induce NF-κB activity and CCR7 expression (most likely through Akt phosphorylation at Ser473 [55]), as well as accelerated tissue invasion and death in a murine T-ALL model. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.