The overexpression of miR-26b decreased Ser473 p-Akt levels (which is indicative of mTORC2 inhibition), while either shRNA to PI3K p110δ or a PI3K p110δ-selective inhibitor (CAL-101) reduced the viability of T-ALL cell lines [43]. This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.