BCL2L11 and acute lymphoblastic leukemia: In particular, it has been shown that rapamycin downregulated the expression of myeloid leukemia cell differentiation 1 (MCL-1), which is a critical regulator of GC-induced apoptosis, as it sequesters the BH3-only proapoptotic protein B-cell lymphoma-2 (Bcl-2) -like protein 11 (BIM) in GC-resistant CEM T-ALL cells [123].