They are used for treating advanced renal cell carcinoma, hormone receptor-positive/HER2-negative breast cancer in postmenopausal women, pancreatic and other selected neuroendocrine tumors, adult renal angiomyolipoma associated with TSC disease, pediatric or adult subependymal giant cell astrocytoma with TSC, and relapsed/refractory mantle cell lymphoma [97]. The gene discussed is ERBB2; the disease is mantle cell lymphoma.