EIF4EBP1 and acute lymphoblastic leukemia: When used in T-ALL cell models, some of these drugs (PI-103, NVP-BEZ235) displayed a more potent proapoptotic activity than rapamycin, and inhibited one of the rapamycin-resistant outputs of mTORC1, i.e., 4E-BP1 phosphorylation [138,139,140].