Combs and colleagues [99] were the first to report the relationship between PPARγ activation and neurodegeneration, and this evidence was supported by several lines of evidence in animal and cellular models of Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), stroke, and traumatic injuries [100]. This evidence concerns the gene PPARG and amyotrophic lateral sclerosis.