The neuropathological features of AD are mainly intracellular neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau protein and extracellular amyloid beta (Aβ) plaques (Mandelkow & Mandelkow, 1998; Serrano‐Pozo, Frosch, Masliah, & Hyman, 2011). This evidence concerns the gene MAPT and Alzheimer disease.