As we gain further insight into the genetic architecture of male CPP, which currently includes genes in pathways implicated in delayed puberty and/or congenital GnRH deficiency (e.g., KISS1, KISS1R, PROKR2) as well as novel genes (e.g., MKRN3, DLK1) [23, 24, 32–35], genetic testing may supersede neuroimaging in standard diagnostic algorithms. This evidence concerns the gene PROKR2 and central precocious puberty.