In this context, CD90 could be a meaningful molecule in the biology of triple negative breast cancer since its overexpression was able to increase the proliferative cell rate (Fig 3), activate the EGFR pathway (Figs 4 and 5) and, also, promote the invasion and migratory capacity in vitro (Fig 3) and in vivo (Figs 7 and 8). This evidence concerns the gene EGFR and triple-negative breast carcinoma.