In conclusion, although some important clinical markers (i.e., insulin sensitivity, blood pressure, fasting plasma glucose, and triacylglycerol concentrations) were not affected by a short-term increase in dietary saturated fat, our data reveals rapid increases in blood lipids (i.e., total cholesterol and LDL-C), liver damage markers, and the proportion of saturated fatty acids within plasma and muscle lipids, which over the long term may contribute to the development of metabolic and/or cardiovascular disease. The gene discussed is INS; the disease is cardiovascular disorder.