Here, we demonstrate a novel mechanism which links our recently discovered autocrine/paracrine CTRP8 activation of the G protein‐coupled receptor RXFP1 with the oncogenic STAT3 signaling pathway predictive of poor clinical outcome in human GBM patients (Birner et al., 2010; Glogowska et al., 2013). Here, STAT3 is linked to glioblastoma.