In summary, the ability of the novel CTRP8‐RXFP1‐STAT3 signaling axis to guard against TMZ‐induced DNA damage and promote survival pathways provide evidence for a novel role of the CTRP8‐RXFP1 system in TMZ chemoresistance in human GBM (Fig. 5). Here, STAT3 is linked to glioblastoma.