This DNA protective function of CTRP8 in the presence of TMZ was abrogated by the specific STAT3 inhibitor S3I‐201 in patient GBM‐1/2 (Fig. 2J, L; Fig. S4E) and U87MG (Fig. 2K, M), while CTRP8 or S3I‐201 alone had no effect (Fig. 2L, M; Fig. S4E). This evidence concerns the gene C1QTNF8 and glioblastoma.