TMZ‐induced cell death was abrogated by CTRP8 in GBM cells, and this cytoprotective role of CTRP8 was RXFP1 dependent and blocked by RXFP1 KD with siRXFP1‐1 or siRXFP1‐2 in patient GBM‐1/2 (Fig. 4A; Figs S2E and S5E) and U87MG (Fig. 4B). This evidence concerns the gene RXFP1 and glioblastoma.