Like RLN2 in other neoplastic models, the interaction of CTRP8 with RXFP1 promoted GBM matrix invasion and coincided with increased production and secretion of lysosomal protease cathepsin‐B, a known prognostic marker of GBM (Glogowska et al., 2013). The gene discussed is RXFP1; the disease is glioblastoma.