We also previously identified lysosomal cathepsins as targets of H2 relaxin, the cognate ligand of RXFP1, and CTRP8 in human thyroid cancer (cathepsin‐D and cathepsin‐L) and GBM (cathepsin‐B), respectively (Glogowska et al., 2013; Hombach‐Klonisch et al., 2006). This evidence concerns the gene RLN2 and thyroid cancer.