Likely initiated by an interaction of RXFP1 with the small G protein Gαi3 to activate the Gαi3‐Gβγ‐PI3K signaling pathway (Nguyen and Dessauer, 2005), our discovery of a novel CTRP8‐RXFP1‐STAT3 signaling cascade in human GBM links this CTRP8‐RXFP1 system to oncogenic STAT3 functional outcomes, including GBM cell survival, angiogenesis, and cell migration/invasion (Aziz et al., 2010; Butler et al., 2013; Ouedraogo et al., 2017). This evidence concerns the gene RXFP1 and glioblastoma.