First, we detected heterozygous GBA c.1093G>A p.Glu365Lys (p.Glu326Lys) and GBA c.1223C>T p.Thr408Met (p.Thr369Met) variants in eight (3 PD and 3 DLB patients, 2 controls) and two (1 PD and 1 DLB patients) brain specimens, respectively. This evidence concerns the gene GBA1 and Lewy body dementia.