In 2015, Ju et al. reported that the addition of uEGF to creatinine ratio (uEGF/Cr) to standard clinical biomarkers [estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR)] improved the prediction of chronic kidney disease (CKD) progression by following-up three independent diverse CKD cohorts [13]. The gene discussed is ALB; the disease is chronic kidney disease.