However, in recent years, a lot of studies have described that tubulointerstitial lesions in Alport syndrome, including tubulointerstitial infiltration by CXCR3-positive T cells in human Alport syndrome and interstitial fibrosis, tubule cell apoptosis, and tubular atrophy in animal models with Alport syndrome [17–20]. This evidence concerns the gene CXCR3 and Alport syndrome.