A study by Tome-Carneiro et al., conducted in type 2 diabetes and hypertensive patients with coronary artery disease, found that consumption of a grape extract fortified with resveratrol (8 mg) for one year down-regulated key inflammatory molecules [Tumor Necrosis Factor-alpha (TNF-α), Interleukin 1 Beta (IL-1b), IL8], in PBMCs [50]. The gene discussed is TNF; the disease is coronary artery disorder.