SMC3 and neuroblastoma: As recent studies suggest that SMC3 hyperacetylation inhibits sister chromatid release at anaphase (Beckouet et al. 2016; Gligoris et al. 2014), it is conceivable that the HDAC8 inhibitory function of TH34 is responsible for the increase of mitotic aberrations and G2/M cell cycle arrest in neuroblastoma cells after treatment with the novel HDAC6/8/10 inhibitor.