In neuroblastoma, the polyamine regulating ODC1 was found co-upregulated with MYCN and correlates with poor outcome in neuroblastoma, suggesting a detrimental role in neuroblastoma biology (Gamble et al. 2012; Hogarty et al. 2008; Lastowska et al. 2007). The gene discussed is ODC1; the disease is neuroblastoma.