HDAC10 and cancer: Moreover, polyamines are known to modulate DNA conformation by strongly binding to the DNA helix (Feuerstein et al. 1990; Matthews 1993), and recently identified roles of HDAC10 include regulation of DNA mismatch and DSB repair in various cancer types such as ovarian carcinoma (Islam et al. 2017; Radhakrishnan et al. 2015).