Interestingly, our top DMR associated with both prenatal As and plasma IGFBP3 in a regulatory region and was located on MIR886. MIR886 was reported to be a tumor suppressor, for which methylation is inversely correlated with expression and is predictive of outcome in acute myeloid leukaemia (Treppendahl et al. 2012). Here, IGFBP3 is linked to neoplasm.