Interestingly, our top DMR associated with both prenatal As and plasma IGFBP3 in a regulatory region and was located on MIR886. MIR886 was reported to be a tumor suppressor, for which methylation is inversely correlated with expression and is predictive of outcome in acute myeloid leukaemia (Treppendahl et al. 2012). This evidence concerns the gene IGFBP3 and acute myeloid leukemia.