As the availability of the homeostatic chemokines increases within the synovium, the cellular arrangement of the ELS becomes increasingly more “organised,”25, 74 eventually enabling the development of a functionally active GC, which support the occurrence of activation‐induced cytidine deaminase‐dependent class‐switching and somatic hypermutation with the production of high affinity, RA‐specific anti‐CCP antibodies.72 The crucial elements and steps of the ELS generation in RA synovial tissue have been depicted in Fig. 1. This evidence concerns the gene CDA and rheumatoid arthritis.