In this study, we used the APOE*3Leiden.CETP mouse as a well-established model for dyslipidemia and atherosclerosis, with a human-like lipoprotein metabolism and atherosclerosis development (See Supplemental material online for more detailed information on the background of the APOE*3Leiden.CETP mice and their response to hypolipidemic drugs; Data Sheet S1). This evidence concerns the gene APOE and metabolic syndrome.