DAO and amyotrophic lateral sclerosis: In a work investigating the function of an RNA binding protein encoded by the HnRNPA2B1 gene, and the effect of the ALS-associated mutation D290V (promoting the protein aggregation in the nucleus and abnormal splicing events), it was found that the most significant and robust splicing change after depletion of hnRNP A2/B1 in the mouse spinal cord was the skipping of exon 9 within DAO gene, yielding to a shorter transcript isoform (Martinez et al., 2016).