NFKB1 and cancer: Another important factor to consider when discussing the relation between cytokines and cancer drug resistance is the fact that the inflammatory master regulator NF-κB is activated by a variety of cytotoxic chemotherapy agents including cisplatin, paclitaxel, docetaxel, and doxorubicin (Nakanishi and Toi, 2005; Li and Sethi, 2010).