One of the most potent inducers of angiogenesis is hypoxia, which activates hypoxia inducible factor 1 (HIF1) in both tumor cells and surrounding stromal cells leading to the production of vascular endothelial growth factor (VEGF), a potent mediator of new vessel growth (Krock et al., 2011). The gene discussed is VEGFA; the disease is neoplasm.