Intriguingly, Hill and colleagues further showed that loss of Tp53 in the stromal compartment disrupts the homeostasis between the epithelial and stromal tissues ultimately leading to loss of Tp53 also in the tumor suggesting that stromal loss may actually precede epithelial Tp53 loss (Hill et al., 2005; Palumbo et al., 2015). This evidence concerns the gene TP53 and neoplasm.