While TP53 has been the major focus of most mechanistic studies, it is conceivable that mutational inactivation of other tumor suppressors as well as epigenetic alterations such as histone modifications and DNA methylation may be responsible for the generation of stromal cells with pro-tumorigenic properties (Hu et al., 2005; Peng et al., 2005; Bar et al., 2009). Here, TP53 is linked to neoplasm.