Fujimoto et al. analyzed the levels of serum POSTN in intrahepatic cholangiocarcinoma patients and observed that these were significantly higher in these patients compared to normal controls and patients with liver cirrhosis, hepatocellular carcinoma, and other malignancies, suggesting that serum POSTN levels could be useful to distinguish between cholangiocarcinoma and other hepatic malignancies (97). Here, POSTN is linked to cirrhosis of liver.