Mutations of the main RTKs transducer—RAS/BRAF—are events more frequent than mutations in RTKs, yet, mutated forms of RTK genes including KIT, ERBB1-4, PDGFR, the EPH and FGFR families, and others are known to govern abnormal signaling driving aberrant growth and survival of melanoma cells (68). The gene discussed is KIT; the disease is melanoma.