CLOCK and metastatic melanoma: In normal skin, we have found a classic pattern of clock gene expression: PERs and CRYs are concomitantly expressed (in phase) and are in antiphase with BMAL1 and CLOCK expression, as expected; on the other hand, in metastatic melanomas such correlations are severely attenuated (Figure 1B), which further corroborates a dysfunctional circadian clock within the tumor.