There were 36 reported cases of GLP-1-RA-related GERD-like symptoms (ROR: 5.61, 95% CI: 3.95–7.96 and IC: 2.17, 95% CI: 1.66–2.67) and GLP-1-RAs were detected in the signal. The gene discussed is GCG; the disease is gastroesophageal reflux disease.