GERD-like symptoms were reported in 36 GLP-1-RAs cases (ROR: 5.61, 95% confidence interval (95% CI): 3.95–7.96 and IC: 2.17, 95% CI: 1.66–2.67) and GLP-1-RAs were detected in the signal. Here, GLP1R is linked to gastroesophageal reflux disease.