The identification of a humanCD14+ macrophage population displaying high cell-surface levels of DC-SIGN, MRC1, and CD163, is supported by our previous finding describing the presence of the CD16hiCD163hiMerTKhi immunosuppressive macrophages in the pleural cavity of patients with active TB (25), and by our first report on DC-SIGN-expressing alveolar macrophages isolated from the bronchoalveolar lavage in patients with pulmonary TB (19). The gene discussed is CD209; the disease is pulmonary tuberculosis.