On the other hand, treatment of mice with chronic TB (4–6 months post-infection) with an anti-TNF-α antibody resulted in rapid death, with disorganized granulomas and a modest increase in bacterial burden (Mohan et al., 2001), although of course in our work we are not abrogating TNF-α function as opposed to Mohan et al. (2001). This evidence concerns the gene TNF and tuberculosis.