These results are in accordance with evidence showing the presence of CD4+ T cells as producers of IFN-γ in patients, which only control the dissemination of the infection (Fujimura et al., 1996; Koga et al., 2002), while IL-17 production is associated with the optimal clearance of S. schenckii and other fungi (Martínez-Álvarez et al., 2014; Ferreira et al., 2015). This evidence concerns the gene CD4 and infection.