However, when mice were treated with systemic anti-CD4 monoclonal antibody, to deplete CD4+ T cells with circulating memory phenotype present in the sdLN, during the infection (13 days), the mice had a significant increase in the skin lesion area, suggesting an important role for the circulating memory CD4+ T cells in the optimal control of a S. schenckii infection (Figure 6D). Here, CD4 is linked to infection.