This notion was not confirmed until 70 years later, when inactivating mutations of the EVER1/TMC6 and EVER2/TMC8 genes accounting for about 50% of all known cases of EV were identified (Ramoz et al., 2002; Orth, 2006, 2008; Imahorn et al., 2017). The gene discussed is TMC8; the disease is epidermodysplasia verruciformis.