TMC8 and epidermodysplasia verruciformis: Shortly after the mapping of two susceptibility loci for EV to chromosomes 17q25 (EV1) and 2p21-p24 (EV2) (Ramoz et al., 1999, 2000), bi-allelic loss-of-function mutations of two adjacent genes termed TMC6 and TMC8, also named EVER1 and EVER2, respectively, located within the EV1 locus, were identified (Ramoz et al., 2002).