The technology has recently been applied for the study or treatment of human diseases such as muscular dystrophy, hemophilia, thalassemia, cystic fibrosis etc. The CRISPR-Cas system has been used for correction of the dystrophic gene in Duchenne muscular dystrophy (DMD) patient-derived induced pluripotent stem cells and restoration of the dystrophin protein in the cells (Li et al., 2015). Here, DMD is linked to Duchenne muscular dystrophy.