Indeed, there were reports showed that the TRAIL-/- or FASL-/- mice or blockage of DR5 or FAS markedly suppressed the pathophysiology of Con A-mediated acute liver injury, suggesting the critical role of cytotoxic effectors released from immune cells in hepatitis development and hepatocyte cell death (Muhammad et al., 2012). This evidence concerns the gene TNFRSF10B and hepatitis A virus infection.