MAPT and Alzheimer disease: Within the 3xTg-AD mice, sex differences have been found in AB plaque load and tau pathology (Billings et al., 2005; España et al., 2010; Oh et al., 2010), the cholinergic system (Perez et al., 2011); neurogenesis (Rodríguez et al., 2008); and stress hormone reactivity (Clinton et al., 2007), but in each case, females showed earlier and more severe pathology than males.