One of the most widely used strains is the 3xTg-AD mouse model (Oddo et al., 2003; Sy et al., 2011) which has three gene mutations (APP-Swedish, PS1M146V and tauP301L), resulting in a phenotype with amyloid beta plaques and tau pathology in the brain as well as deficits in cognitive function (Oddo et al., 2003; Billings et al., 2005; Stevens and Brown, 2015; Stover et al., 2015). Here, MAPT is linked to Alzheimer disease.