However, in the three HD mouse models, at late stages of the disease, nuclear inclusions were found in 30%–50% of the neurons, 30% of the S100B-positive glial cells, 4%–10% of the GFAP-positive astrocytes, 3%–10% of the oligodendrocytes, and 0%–2% of the microglia (Jansen et al., 2017). This evidence concerns the gene S100B and Huntington disease.