Furthermore, in LPS or chronic stress-induced rodent models of depression, rodents displayed depressive-like behavior and activation of NLRP3 inflammasome in some brain areas such as the hippocampus (Lu et al., 2014; Zhang et al., 2014), which were decreased after standard antidepressant medications (Pan et al., 2014; Du et al., 2016). This evidence concerns the gene NLRP3 and major depressive disorder.