We found that Smac mimetics such as AZD5582, SM164 and BV6 could cooperate with IFNγ to profoundly (> 90%) induce cell death in H1975, HCC827 and H1437 NSCLC cell lines that expressed STAT1 [27], a central molecular for IFNγ signaling. Here, IFNG is linked to non-small cell lung carcinoma.