The synergetic effects of IFNγ with Smac mimetics AZD5582, SM164 or BV6 on cell death was also observed in NSCLC cell line H1437 harboring p53 mutation; however Smac mimetics alone or AZD5582 plus poly(I:C) had only a minor effect on the cell viability (Fig. 6a–c). The gene discussed is TP53; the disease is non-small cell lung carcinoma.