Similar to the H1975 cell line, we found that Smac mimetics AZD5582 or SM164 cooperated with IFNγ, but not with TNFα, IFNα, IFNλ, TRAIL or poly(I:C) to induce cell death in HCC827 NSCLC cell line overexpressing EGFR and harboring L858R mutation (Fig. 5a–e). The gene discussed is IFNG; the disease is non-small cell lung carcinoma.