Out of n = 15 possible target antigen pairs, we identify CD33/TIM3 and CLL1/TIM3 as the most suitable antigen combinations, with high coexpression in most AML samples and largely absent coexpression in normal hematopoiesis and non-hematopoietic tissues, excluding tissues with known immune infiltration. Here, HAVCR2 is linked to acute myeloid leukemia.