PRMT5 and neoplasm: Since the growth/survival effects of PRMT5 inhibitors are time-dependent (Fig. 2D,F, Supplementary Figure S5D,E), the anti-proliferative activity of GSK3203591 was further profiled in a panel of 240 cancer cell lines representing 40 different tumour types in a 10-day growth/death assay (Supplementary Figure S1F, Supplementary Table 3).