Whereas both MBNL1 and MBNL2 were sequestered in ribonuclear foci of DM1 myoblasts (Fig. 4h, l), antagomiRs-23b and -218 robustly increased the protein expression and restored their distribution in the cytoplasm and in the cell nucleus (Fig. 4i, j, m, n). The gene discussed is MBNL2; the disease is myotonic dystrophy type 1.