PLA2G6 and Spastic paraplegia: For example, a variety of clinical and pathological phenotypes have been reported for alterations within the same genes that cause some of the neuroaxonal dystrophy syndromes in humans (Revesz et al. 2015; Arber et al. 2016); PLA2G6 gene mutations can give a spectrum of disease phenotypes as well as classical INAD including dystonia-parkinsonism syndromes and spastic paraplegia (Gregory et al. 2008; Ozes et al. 2017).