Proband 2 underwent a next-generation sequencing panel of 12 genes associated with RASopathies (PTPN11, SOS1, RAF1, KRAS, NRAS, BRAF, MEK1, MEK2, HRAS, SHOC2 (exon 02), CBL, and SPRED1) and no other variants in any of these genes were identified. This evidence concerns the gene BRAF and RASopathy.