FENDRR and neoplasm: The methylation level in promoter region was lower than other positions in lincRNA, and was negatively correlated with gene expression.There were 427 lincRNA genes showed differential DNA methylation in their promoter regions in tumor and adjacent tissues.Among these, 15 lincRNA genes showed differential gene expression and negatively correlated with DNA methylation, including FENDRR (a tumor progression and metastasis gene) whose high methylation in its promoter showed poor survival in lung adenocarcinoma.