In overweight and obese controls (mean age: 25.46 ± 13.77 years, similar age than overweight and obese PKU, p = 0.72): insulin and HOMA-IR concentrations also were lower in the controls (insulin: 12.63 ± 5.87 vs 20 ± 9.39 mIU/L; p = 0.014; Homa IR 2.86 ± 1.37vs 3.95 ± 2.17, p = 0.19). The gene discussed is INS; the disease is phenylketonuria.