PRIMA1 and adenoma: We have also identified hypermethylated markers (mal, T-cell differentiation protein (MAL), proline rich membrane anchor 1 (PRIMA1), prostaglandin D2 receptor (PTGDR) and secreted frizzled related protein 1 (SFRP1)) in CRC and adenoma using bisulfite sequencing [15] and determined a common ten-gene methylation signature in colorectal adenomas and CRC based on methylation qPCR arrays [16].