In CRC samples hypermethylated DMRs were found in the promoter regions of 11 genes such as caspase 8 (CASP8), cyclin dependent kinase inhibitor 1A and 2A (CDKN1A and CDKN2A), insulin-like growth factor binding protein 3 (IGFBP3), sestrin 2 (SESN2) and tumor protein p73 (TP73), while seven TP53 pathway genes including G2 and S-phase expressed 1 (GTSE1) showed hypomethylation in their promoters. The gene discussed is SESN2; the disease is colorectal carcinoma.