Seven of the top50 markers (BNC1 [16], DKK2 [48–50], HS3ST2 [51], MIR124–3 [52], SDC2 [14, 34, 53, 54], TFPI2 [55, 56] and ZIC1 [57]) were previously described as methylated genes in CRC. The gene discussed is ZIC1; the disease is colorectal carcinoma.