In the AD versus NAT comparison, 94% of the top50 highly methylated DMRs were found in CpG islands including generally known CRC-associated DNA methylation markers like Fli-1 proto-oncogene, ETS transcription factor (FLI1), GATA binding protein 4 (GATA4) and nerve growth factor receptor (NGFR). The gene discussed is FLI1; the disease is Alzheimer disease.